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SM ISO690:2012 DESEATNICOVA, Elena, FRUNZE, Valeria, AGACHI, Svetlana, GROPPA, Liliana. Bone and thyroid gland pathology in rheumatoid arthritis. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 134. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | |||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | |||||||
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Background. Thyroid pathology is frequently associated with autoimmune rheumatic diseases. Moreover, thyroid pathology is one of the risk factors for osteoporosis, on the other hand osteoporosis is often diagnosed in patients with rheumatoid arthritis. Abovementioned served as the basis for our work. Objective of the study. To study the presence of thyroid gland pathology and osteoporosis in patients with rheumatoid arthritis (RA) and to determine their correlation with disease activity in RA. Material and Methods. A total of 78 RA patients and 82 non-RA patients were included in the study. The presence of thyroid gland pathology was estimated by TSH, free thyroxine (fT4), TgAb and TPOAb. Bone mineral density was measured by DXA, diagnosis of osteoporosis was made by WHO criteria. Disease activity in RA was evaluated using DAS-28-ESR. All the data were analyzed statistically. Results. The mean disease duration of RA was 10,1±5,6 years. Clinical hypothyroidism was reported in 20.33% of the RA patients and in 2.08% of the non-RA patients. Clinical hyperthyroidism was found in 3.38% of the patients with RA. Osteoporosis at the level of hip was confirmed in 41% of cases of RA and only in 17% of the control group, while osteoporosis at the level of lumbar spine was more common for non-RA patients in 48% VS. 13% in RA. High disease activity was in 76.27% of the patients. High disease activity positively correlated with the presence of osteoporosis and thyroid gland pathology (r= 0,58 and r=0,34), the presence of thyroid gland pathology was associated with lower BMD. Conclusion. The association between thyroid pathology, osteoporosis and RA was confirmed. Clinical hypothyroidism and bone loss at hip level were more characteristic for RA. Presence of both osteoporosis and thyroid gland pathology correlated with high disease activity by DAS28- ESR. |
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Cuvinte-cheie rheumatoid arthritis, thyroid gland pathology, osteoporosis, artrita reumatoidă, patologia glandei tiroide, osteoporoza |
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