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Articolul precedent |
Articolul urmator |
561 23 |
Ultima descărcare din IBN: 2023-09-29 13:05 |
Căutarea după subiecte similare conform CZU |
57.085:615.277 (1) |
Biological techniques, experimental methods and equipment in general (194) |
Medicaments according to their principal action (395) |
SM ISO690:2012 GARBUZ, Olga, TODERASH, Ion, RAILYAN, Nadejda, TSAPKOV, Victor I., GULYA, Aurelian. Some inorganic and organic biological agents. In: Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii), 2021, nr. 6(146), pp. 132-140. ISSN 1814-3237. DOI: https://doi.org/10.5281/zenodo.5702096 |
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Studia Universitatis Moldaviae (Seria Ştiinţe Reale şi ale Naturii) | ||||||
Numărul 6(146) / 2021 / ISSN 1814-3237 /ISSNe 1857-498X | ||||||
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DOI:https://doi.org/10.5281/zenodo.5702096 | ||||||
CZU: 57.085:615.277 | ||||||
Pag. 132-140 | ||||||
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Based on the known methods and their modifications, 3 compounds were synthesized: 2-formylpyridine N(4)-phenylthiosemicarbazone, complex copper(II) [Cu(L)Cl] with 2-formylpyridine N(4)-phenylthiosemicarbazone ligand, copper(II) mixed-ligand complex chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1sulfonamide)copper [Cu(Str)(L)Cl]. The antiproliferative properties of these compounds towards cancer cell lines MeW-164 and HeLa have been investigated. The tested compounds demonstrated antiproliferative and selective activity towards cancer cells. The tested compounds inhibit the activity of LOX. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay. It was found that the tested compounds have a lower toxicity than DOXO. Theoretical pharmacokinetics (Lipinski's rule, PSA) of CMT-22, CMT-67 and CMT-68 supports further in vivo studies. |
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Cuvinte-cheie anticancer compound, DNA fragmentation, apoptosis, antilipoxygenase activity, Lipinski’s rule, compus anticancer, fragmentarea ADN-ului, apoptoză, activitate antilipoxigenază, regula lui Lipinski |
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