Objectives: establishing impact of vascular risk factors, particularly migraine on severity of Parkinson’s disease. Methods: Analysis included 29 consecutive PD patients from Moldovan cohort (20.80009.8007.39), mean age 63.3
8.1 yo, mean disease duration 48.9
12.9 mo., mean disease onset age of 59.0
8.7 y. Motor assessment (UPDRS II scale, Tremor Score, Akinetic-rigid Score), quality of life impairment (PDQ39), cognitive performance (MoCA) were conducted. Presence of vascular risk factors (FRV), including migraine (Mg), QRISK3 scores and relative cardiovascular risk were determined. Results: Twenty-five (86.2%) of total PD patients had VRF. Migraine present in 41% of them. PDþVRF was associated with higher scores of disease severity: UPDRS II 46.73
11.75 (vs. 42.75
23.71), TrScore 0.94
0.56 (vs. 0.88
0.33), ARScore 0.82
0.53 (vs. 0.70
0.12), higher PDQ39 52.78
27, 81 (vs. 41.25
20.16) and lower cognitive MoCA scores 21.75
4.07 (vs. 22.60
3.29), not reaching statistical significance. PDþMg had higher PDQ39 index: 55.00
31.12 (vs. 48.88
24.35) and lower MoCA cognitive scores – 21.48
4.20 (vs. 22.09
3.90), no statistically significant difference. PDþMg patients had significantly higher relative cardiovascular risk scores – 2.80
6.84 (vs. 1.53
0.66, p ¼ 0.02). Conclusions: Vascular risk factors, if present in PD patients, may predict a worse motor and cognitive performance. Migraine presence significantly increases the patients cardiovascular risk