Background: Pain with various localizations are frequently associated with primary headaches. Objective: The aim of this study was to evaluate the pain comorbidity of migraine (MG) and tension-type headache (TTH) in adolescents in the Republic of Moldova. Method: In total there were 1486 adolescents diagnosed with primary headache (10–19 y.o.) recruited from urban and rural area of the country. Diagnosis was based at ICHD-3 (2018) criteria. Results: Pain comorbidity was more frequently in adolescents diagnosed with MG compared to those with TTH (65.9% vs. 58.3%, p<0.001). Depending on the gender, we highlight a higher intensity of the phenomenon among girls than in boys (66.3% vs 43.8%, p<0.001). In adolescents with MG the prevalence of pain with extracephalic location is higher in girls than in boys (72.8% vs. 52.8%, p<0.001). In the case of TTH boys suffer less often than girls (49.9% vs. 68.6%, p<0.001). Adolescents with MG reported more often abdominal pain (73.1%), unspecified back pain (72.8%) and low back pain (72%). Adolescents with TTH – neck pain (36.6 %), face pain (32%) and chest pain (31.7%). Conclusion: According to the present study, adolescents suffering from primary headaches reported more frequently abdominal pain (73.1%), low back pain (72%) and cervical pain, with a difference in the degree of their manifestation depending on gender and type of primary headaches.