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SM ISO690:2012 ROTARU, Lilia. Environmental toxic factors and clinical pattern of Parkinson's disease. Preliminary results of a cohort study. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 199. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | |||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | |||||||
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Background. The interaction of genetic and environmental factors is important for Parkinson's disease (PD) pathogenesis. Excessive exposure to certain environmental factors is associated with an increased PD risk. Objective of the study. Finding the influence of excessive exposure to toxic environmental factors on clinical pattern of PD. Material and Methods. Se prezintă datele preliminare ale studiului de cohortă a pacienților cu BP din Republica Moldova. Au fost examinați 111 pacienți consecutivi cu BP, prin anamnestic fiind constatat contactul cu substante toxice (specificate în sectiunea Rezultate). Grupeledefinite ca: (1) Contact substanțe toxice prezent (CSTox+) și (2) absent (CSTox-). Results. ToxSC was found in 33p. (29.73%): petrol intake - 10p. (9%), diesel intake - 4p. (3.6%), petrol + diesel intake - 6p. (5.4%), exposure to pesticides - 7p. (6.3%), solvents - 3p (2.7%), reinforced concrete (polystyrene) - 1p. (0.9%), welding gas - 1p. (0.9%), freon - 1p. (0.9%). In ToxSC+ patients, bradykinesia was the most often PD onset symptom (57.6%, p = 0.008), at an insignificantly younger age (59.24 ± 6.93 vs. 60.95 ± 8.86 years, p <0.005), more frequently as an akinetic-rigid PD type (64.7%, p = 0.040). Levodopa equivalent daily doses in ToxSC+ patients were higher (659.02 ± 232.46 vs. 483.77 ± 355.41, p = 0.042). Conclusion. In this study, excessive exposure to toxic environmental factors was more common in men and rural residents and was associated with the akinetic-rigid type of Parkinson's disease and higher doses of dopaminergic drugs, indicating a higher severity of motor impairment. |
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Cuvinte-cheie Parkinson's disease, toxic environmental factors, boala Parkinson, factori toxici de mediu |
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