Accumulation and Effect of Silver Nanoparticles Functionalized with Spirulina platensis on Rats
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RUDI, Ludmila, ZINICOVSCAIA, Inga, CEPOI, Liliana, CHIRIAC, Tatiana, AUTOR, Nou, CEPOI, Anastasia, GROZDOV, Dmitrii. Accumulation and Effect of Silver Nanoparticles Functionalized with Spirulina platensis on Rats. In: Nanomaterials, 2021, vol. 11, pp. 1-14. ISSN 2079-4991. DOI: https://doi.org/10.3390/nano11112992
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Nanomaterials
Volumul 11 / 2021 / ISSN 2079-4991 /ISSNe 2079-4991

Accumulation and Effect of Silver Nanoparticles Functionalized with Spirulina platensis on Rats

DOI: https://doi.org/10.3390/nano11112992

Pag. 1-14

Rudi Ludmila1, Zinicovscaia Inga234, Cepoi Liliana1, Chiriac Tatiana1, Autor Nou2, Cepoi Anastasia1, Grozdov Dmitrii2
 
1 Institute of Microbiology and Biotechnology ,
2 Joint Institute of Nuclear Research,
3 Horia Hulubei National Institute of Physics and Nuclear Engineering,
4 Institute of Chemistry
 
Proiecte:
 
Disponibil în IBN: 9 noiembrie 2021


Rezumat

The effect of unmodified and functionalized Spirulina platensis biomass silver nanoparticles on rats during prolonged oral administration was assessed. Silver nanoparticles were characterized by using transmission electron microscopy, while their uptake by the biomass was confirmed using scanning electron microscopy and energy dispersive analysis. The content of silver in the different organs of rats after a period of administration (28 days) or after an additional clearance period (28 days) was ascertained by using neutron activation analysis. In animals administrated with the unmodified nanoparticles, the highest content of silver was determined in the brain and kidneys, while in animals administrated with AgNP-Spirulina, silver was mainly accumulated in the brain and testicles. After the clearance period, silver was excreted rapidly from the spleen and kidneys; however, the excretion from the brain was very low, regardless of the type of nanoparticles. Hematological and biochemical tests were performed in order to reveal the effect of nanoparticles on rats. The difference in the content of eosinophils in the experimental and control groups was statistically significant. The hematological indices of the rats did not change significantly under the action of the silver nanoparticles except for the content of reticulocytes and eosinophils, which increased significantly. Changes in the biochemical parameters did not exceed the limits of normal values. Silver nanoparticles with the sizes of 8–20 nm can penetrate the blood–brain barrier, and their persistence after a period of clearance indicated the irreversibility of this process.

Cuvinte-cheie
Spirulina platensis, Silver Nanoparticles, hematological indices, Biochemical parameters, neutron activation analysis