Assessment of TiO2 Nanoparticles Accumulation in Organs and Their Effect on Cognitive Abilities of Mice
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ZINICOVSCAIA, Inga, IVLIEVA, Alexandra, PETRITSKAYA, Elena, ROGATKIN, Dmitriy, YUSHIN , Nikita, GROZDOV, Dmitrii, VERGEL, Konstantin, MAMULOVA KUTLAKOVA, Katerina. Assessment of TiO2 Nanoparticles Accumulation in Organs and Their Effect on Cognitive Abilities of Mice. In: Physics of Particles and Nuclei Letters, 2021, vol. 18, pp. 378-384. ISSN 1547-4771. DOI: https://doi.org/10.1134/S1547477121030146
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Physics of Particles and Nuclei Letters
Volumul 18 / 2021 / ISSN 1547-4771

Assessment of TiO2 Nanoparticles Accumulation in Organs and Their Effect on Cognitive Abilities of Mice

DOI: https://doi.org/10.1134/S1547477121030146

Pag. 378-384

Zinicovscaia Inga123, Ivlieva Alexandra4, Petritskaya Elena4, Rogatkin Dmitriy4, Yushin Nikita1, Grozdov Dmitrii1, Vergel Konstantin1, Mamulova Kutlakova Katerina5
 
1 Joint Institute of Nuclear Research,
2 Horia Hulubei National Institute for Physics and Nuclear Engineering,
3 Institute of Chemistry,
4 M.F. Vladimirsky Moscow Regional Scientific Research Clinical Institute,
5 VSB - Technical University of Ostrava
 
Disponibil în IBN: 29 iunie 2021


Rezumat

Because of good optical and electrical properties, TiO2 nanoparticles are widely used in many fields of industry and medicine. To assess the effect of TiO2 nanoparticles on mice cognitive abilities and their accumulation in different organs, daily, up to 2-month period, experimental mice were administrated with TiO2 nanoparticles solution. Accumulation of titanium in blood, brain, liver, kidney, lungs and feces was assessed by neutron activation analysis. Cognitive abilities in mice before and after TiO2 nanoparticles administration were evaluated in the Morris water maze behavioral test. The amount of titanium in all organs was below the limits of detection of the method and in feces it constituted 74 ± 7 µg/g. In the main Morris water maze behavioral test at the control points statistically significant differences were found in the parameters of treks between capable experimental and control animals.