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Ultima descărcare din IBN: 2021-10-11 22:21 |
Căutarea după subiecte similare conform CZU |
616.127-005.8:575.1 (1) |
Pathology of the circulatory system, blood vessels. Cardiovascular complaints (975) |
General genetics. General cytogenetics (427) |
SM ISO690:2012 RODOMAN, Iulia, PALII, Ina, DORIF, Alexandr, SAKARA, Viktoria K.. miRNA profile in cardiomyopathies with dystrophine deficiency. In: International Congress of Geneticists and Breeders from the Republic of Moldova, Ed. 11, 15-16 iunie 2021, Chişinău. Chișinău, Republica Moldova: Centrul Editorial-Poligrafic al Universităţii de Stat din Moldova, 2021, Ediția 11, p. 57. ISBN 978-9975-933-56-8. DOI: https://doi.org/10.53040/cga11.2021.039 |
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International Congress of Geneticists and Breeders from the Republic of Moldova Ediția 11, 2021 |
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Congresul "International Congress of Geneticists and Breeders from the Republic of Moldova" 11, Chişinău, Moldova, 15-16 iunie 2021 | ||||||
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DOI:https://doi.org/10.53040/cga11.2021.039 | ||||||
CZU: 616.127-005.8:575.1 | ||||||
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Duchenne muscular dystrophy (DMD) is the most common and severe form of progressive muscular dystrophy, with an incidence of 1 to 3500–6000 live births. In patients with DMD, the problem of cardiovascular disorders is relevant, because the damage to the heart muscle and the cardiac conduction system is a factor that worsens prognoses. Long and short non-coding RNAs are differentially expressed in DMD and have a mechanism of action through targeted mRNAs. A subset of muscle-enriched miRNAs, the so-called myomiRs (miR-133, miR-206, miR-208), are grown in the serum of patients with DMD and in animal models with dystrophin deficiency, which may present an important biomarker. Purpose: to estimate the role of miR133a-3p, mir133b-3p, miR206-3p, miR208a3p, miR208b-3p in the development of cardiomyopathy in children with DMD. Material and methods: the retrospective study included 20 patients with confirmed molecular-genetic diagnoses of DMD and 9 patients in the control group. The anamnesis and clinical-paraclinical investigations, such as blood biochemistry (ALAT, ASAT, LDH, CK, CK-MB), EAB, electrocardiogram, echocardiography plus color Doppler were performed in the cardiology unit of the PMHI Mother and Child Care Institute. The extraction and analysis of the above-mentioned miRNA using the qPCR and RT methods were performed in the Genetic Center of Excellence PMHI Mother and Child Care Institute. Results: for the first time in the Genetic Center of Excellence, quantitative miRNA extraction was obtained. The protocol and study results will be presented at the congress. Conclusions: additional scientific evidence shows that nRNAs also play a role in dystrophin expression; In this way, their modulations could represent a potential therapeutic strategy to increase dystrophin levels in combination with other gene therapies. |
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