The role of proinflammatory cytokines in heart failure in children in combination with pulmonary hypertension
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616.12-008.331.1]:616-007.2-053.2 (1)
Pathology of the circulatory system, blood vessels. Cardiovascular complaints (975)
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PALII, Ina, EŞANU, Veronica, EŞANU, Valeriu. The role of proinflammatory cytokines in heart failure in children in combination with pulmonary hypertension. In: International Journal on Immunorehabilitation, 2016, nr. 1(18), pp. 49-49-1. ISSN 1562-3629.
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International Journal on Immunorehabilitation
Numărul 1(18) / 2016 / ISSN 1562-3629

The role of proinflammatory cytokines in heart failure in children in combination with pulmonary hypertension

CZU: 616.12-008.331.1]:616-007.2-053.2

Pag. 49-49-1

Palii Ina12, Eşanu Veronica12, Eşanu Valeriu12
 
1 Institute of Mother and Child,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 13 mai 2021


Rezumat

Introduction: Proinflammatory cytokines play an important role in the pathogenesis of heart failure (HF), and in pulmonary
hypertension (PH). Aim: Determination of pathophysiological role of proinflammatory cytokines IL-1ß, IL-6 and TNFα in HF in children
secondary to congenital systemic-to-pulmonary shunts complicated with PH of different degree. Materials and methods: The study comprised 70 children: from 1 month to 18 years with HF secondary to systemic-
pulmonary shunts simple, compound and complex with PH (anatomical and pathophysiological classification, modified
from Venice 2003 ESC PAH Guide 2013). Depending on the degree of PH patients were divided into two: group I – 16 children with HF and moderate PH (PSAP 50–70% of the systemic) and group II – 54 children with HF and PH severe degree
(PSAP> 70% of the systemic). After FC NYHA / Ross, in the group I prevailed children with FC II and III, and in the
second – FC III and IV (p<0.001). The control group consisted of 10 kids basically healthy with innocent heart murmur. The groups were comparable by age and sex. Proinflammatory cytokines were determined by immunoferment screening method. Results: In the patients of group I the serum level of IL-1β was 3.71±0.37 pg/ml vs 10.49±1.56 in the II group (p<0.05) and 2.74±0.53 healthy children (p<0.05, p<0.001). The amount of IL-6 was 5.5±0.83 pg/ml in group I vs 8.61±0.83 in group
II (p = 0.05) and 1.63±0.62 in healthy (p <0.001). TNF-alpha level was 3.62±0.37 in group I compared with 6.88±0.9 in
group II (p>0.05) and in healthy controls – 1.82±0.91 pg/ml (p<0.05, p <0.001).
Conclusions: Proinflammatory cytokines IL1β, IL-6 and TNFα are relevant to the pathophysiology of HF secondary to
congenital shunts associated with PH, their levels increasing with the severity of this pathology – FC NYHA/ROSS of HF and level of PH.