Republic of Moldova, as well as other countries, has a problem with contaminated sites by toxic organic substances (POPs, PAHs, BTEX, etc.), which potentially have a strong impact to human health. It is also important for major challenges of natural resources: 1) provision of food and fiber; 2) energy security; 3) water security; 4) climate change abatement; 5) biodiversity protection; 6) ecosystem service delivery. By being able to perform five functions, among them storing, filtering and transforming of nutrients, substances and water, soil largely contributes to the quality of air, food and water, which has a direct link to human health. There are two kinds of soil contamination: local soil contamination due to the intensive industrial or agriculture activities or accidents, which introduce excessive amount of contaminants in soil; diffuse soil contamination from different sources due to their emission, transformation and transport to soil by natural media (air, water). At global level, the estimates of contaminated sites and potentially contaminated are then between 10 million and 20 million sites. At the same time European countries have undergone, only 5% remediation of the identified and potentially contaminated sites and the number of recorded polluted sites across whereas the number of recorded contaminated site Europe is expected to increase by 50% by 2025. People are mainly exposed to toxic organic pollutants by dust and vapor coming from soil, ingestion of contaminated soil particles or contaminated food, and dermal absorption through the skin. The ranking by possible health effect at the regional level was made in this study for POPs contaminated sites by example of Republic of Moldova using GIS approaches. The obtained results showed zones with high dangerous for human health from POPs contaminated sites. The population density was included in the regional risk evaluation of POPs impact to public health. Other contaminated sites were evaluated also for potential risk for human health (PAHs, BTEX). The local exposure of toxic substances and human health risk was evaluated by example of the conceptual models for individual contaminated sites. Toxic organic compounds depend mainly on their potential absorption in the food chain measured by their distribution coefficient (octanol/water), Henry constant, water solubility, half-life and bio-concentration factor. Remediation of contaminated soil is considered as the management of the contaminant at a site to prevent, minimize or mitigate damage to human health, property or the environment. The bioremediation technology is a perspective method for the reducing of risks the environment and public health from contaminated site. The scientifically based program is essential for the realization of risk mitigation actions. Contaminated site management needs in the further development of legislative framework, the strengthening of the institutional capacity for the realization of remediation projects and respective monitoring and control of the carried out work.