Microbiological activity of the activated carbon impregnated with silver and selenium nanoparticles
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PETUHOV, Oleg, POVAR, Igor, GORINCIOI, Elena, LUPASCU, Tudor, SPINU, Oxana. Microbiological activity of the activated carbon impregnated with silver and selenium nanoparticles. In: Chemistry, physics and technology of surface : Workshop "Nanostructured biocompatible / bioactive materials", 24-25 mai 2017, Kyiv. Kyiv, Ukraine: Chuiko Institute of Surface Chemistry of National Academy of Sciences of Ukraine, 2017, p. 127. ISBN 978-966-02-8223-0.
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Chemistry, physics and technology of surface 2017
Conferința "Chemistry, physics and technology of surface"
Kyiv, Ucraina, 24-25 mai 2017

Microbiological activity of the activated carbon impregnated with silver and selenium nanoparticles


Pag. 127-127

Petuhov Oleg, Povar Igor, Gorincioi Elena, Lupascu Tudor, Spinu Oxana
 
Institute of Chemistry of the Academy of Sciences of Moldova
 
Disponibil în IBN: 31 iulie 2020


Rezumat

Activated carbon (AC) is widely used in the pharmaceutical field for the
body detoxification and treatment of external wounds. A recent application of
AC in clinical medicine is represented by its use in the absorbent material
dressings for bandaging the superficial and deep wounds, but also in recovery of
post-surgical trauma. These bandages help to create a favorable environment for
rapid treatment of wounds and do not allow the spread of infection. AC
enhances the process of hemocoagulation, accumulates the exudate on surface,
creates a barrier to penetration of microorganisms from the outside and in
combination with the dressing material prevents dehydration of the wound. This
study was aimed at: impregnating the AC with Enoxil medicinal preparation, as
well as Ag or Se nanoparticles, qualitative and quantitative study of the
processes to immobilize the neutral nanoparticles on intact and oxidized CA and
testing the microbiological activity of the obtained AC samples. Microbiological
analyses of the AC samples impregnated with Enoxil preparation and Ag or Se
nanoparticles were carried out on Gram-negative E. coli bacteria and Candida
albicans fungus strain.
The AC samples impregnated with nanoparticles have a delayed action on
the E. coli bacteria, the bactericidal effect being noted only after 4 h for Se and
24 h for Ag nanoparticles, respectively. In the case of Candida albicans fungi,
for the sample containing Se nanoparticles there has been attested a period, in
which the preparation was passive too, but a sharp drop in the number of
colonies occurred thereafter. These observations may be explained by the
presence of a protective coating the nanoparticles, which do not allow them to
aggregate and interact with the atmospheric oxygen, but also prevents the direct
contact with the microorganisms. The AC sample impregnated with Enoxil
shows bactericidal properties after 4 h in the case of E. coli and inhibits growth
of Candida albicans fungi as well. The activity of the modified AC on E. coli
bacteria decreases in the series: AC-Enoxil > AC-Se > AC-Ag, while on
Candida albicans fungi: AC-Ag > AC-Enoxil > AC-Se, correspondingly.
Acknowledgements
The research leading to these results has received funding from the People Programme (Marie Curie
Actions) of the European Union's Seventh Framework Programme FP7/2007-2013/ under REA grant
agreement no. PIRSES-GA-2013-612484.