Purpose: Ovarian torsion, being a gynecological emergency, requires to be rapidly diagnosed and treated with
minimal consequences on ovarian function after the removal of torsion. As ischemia modified albumin (IMA) is
considered a good biomarker in diverse ischemic diseases, the aim of our study was to determine the effect of different
ovarian torsion/detorsion models on serum and ovarian homogenates levels of IMA in an experimental study.
Methods: IMA was measured in the serum and ovarian homogenates of 7 groups of female rats (10 animals in
each group): 1 - control (no intervention); 2 - sham (only laparotomy); 3 - ischemia group: 3 hours ovarian torsion
(OT); 4 - 3 hours OT (ischemia), 1 hour simple reperfusion; 5 - 3 hours ischemia, 1 hour controlled reperfusion that
was assured during the first two minutes by opening and closing the clips on the ovarian pedicles in 10 seconds intervals,
followed by simple reperfusion; 6 - 3 hours ischemia, 24 hours simple reperfusion; 7 - 3 hours OT, 24 hours
controlled reperfusion. The results were analyzed by Welch’s ANOVA and Spearman correlation. Results: Ischemia
increases the IMA in both serum and ovarian homogenates compared to control and sham groups. The controlled
reperfusion groups had a statistically significant lower IMA in serum compared to simple reperfusion groups. IMA
was found to be higher in the ovarian homogenates of simple reperfusion compared to controlled reperfusion groups.
Conclusion: Our results suggest that controlled reperfusion prevent the processes that increase the IMA in ovarian
torsion.