New antifungal and antibacterial nitrogen containing terpenes

Ciocarlan Alexandru; Aricu Aculina; Bîrîiac Andrei; Lungu Lidia; Nicolescu Alina Florica; Deleanu Călin; Vornicu Nicoleta

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2023-09-19 20:17

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CIOCARLAN, Alexandru, ARICU, Aculina, BÎRÎIAC, Andrei, LUNGU, Lidia, NICOLESCU, Alina Florica, DELEANU, Călin, VORNICU, Nicoleta. New antifungal and antibacterial nitrogen containing terpenes. In: The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova, 28-30 mai 2014, Chișinău. Chișinău, Republica Moldova: Institutul de Chimie al AȘM, 2014, p. 196.

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The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova 2014

Conferința "The International Conference dedicated to the 55th anniversary from the foundation of the Institute of Chemistry of the Academy of Sciences of Moldova"
Chișinău, Moldova, 28-30 mai 2014

New antifungal and antibacterial nitrogen containing terpenes

Pag. 196-196

Ciocarlan Alexandru¹, Aricu Aculina¹, Bîrîiac Andrei¹, Lungu Lidia¹, Nicolescu Alina Florica², Deleanu Călin²³, Vornicu Nicoleta⁴

¹ Institute of Chemistry of the Academy of Sciences of Moldova,
² “Petru Poni” Institute of Macromolecular Chemistry,
³ "C.D. Nenitzescu" Centre of Organic Chemistry, Romanian Academy,
⁴ Metropolitan Center of Research TABOR, The Metropolitanate of Moldavia and Bukovina

Disponibil în IBN: 22 iunie 2020

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Rezumat

Based on natural diterpenes (+)-larixol and (-)-sclareol a series of new nitrogen
containing compounds were synthesized. The homodrimanic and drimanic oximes 3 and 4
functionalized in the ring B are reported for the first time. All compounds were screened for their
in vitro antifungal and antibacterial activities against pure culture of three fungi species
(Aspergillus niger, Penicillium frequentans, Alternaria alternata) and against both Gramnegative
(Pseudomonas aeruginosa) and Gram-positive bacteria (Bacillus polymyxa). The amide
1 and oximes 2-4 showed good to acceptable antibacterial and antifungal activity in comparison
with the reference compounds Caspofungin and Kanamycin [1-3]. The results expressed in MIC
values (minimum inhibitory concentration) are reported in Table.

Results of "in vitro" antimicrobial and antifungal activity testing of compounds 1-4.

References:
1. National Committee on Clinical Laboratory Standards (NCCLS), “Antimicrobial Susceptibility
Standards (ATS)”, ed. 2003, for M7 (CMI) and M100.
2. Buiuc D., “Determinarea sensibilităţii la medicamente antimicrobiene: tehnici cantitative în
“Microbiologie clinică”. Editura Didactică şi Pedagogică, Bucureşti, vol. I, 1998, p. 438-442.
3. Garber G., “An overview of fungal infections”, Drugs, 2001, 61, 1-12.