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Ultima descărcare din IBN: 2023-10-20 10:13 |
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616.61-008.9-092.9:546.56 (1) |
Pathology of the urogenital system. Urinary and sexual (genital) complaints. Urology (392) |
Inorganic chemistry (450) |
SM ISO690:2012 SARDARI, Veronica, PANTEA, Valeriana, GULYA, Aurelian, TAGADIUC, Olga, ANDRONACHE, Lilia, SHVETS, Inna, TSAPKOV, Victor I., GUDUMAK, V.. Thiol-disulfide metabolism in kidney tissue at the administration of some copper coordination compounds. In: Moldovan Medical Journal, 2020, nr. 2(63), pp. 12-17. ISSN 2537-6373. DOI: https://doi.org/10.5281/zenodo.3865976 |
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Moldovan Medical Journal | ||||||
Numărul 2(63) / 2020 / ISSN 2537-6373 /ISSNe 2537-6381 | ||||||
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DOI:https://doi.org/10.5281/zenodo.3865976 | ||||||
CZU: 616.61-008.9-092.9:546.56 | ||||||
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Thiol-disulfide metabolism is essential for normal function of the organism. Thus the interest of the scientists in this area of research continues to grow. Material and methods: Copper coordination compounds (CCC), derivatives of thiosemicarbaside (CMD-4, CMJ-33, CMT-67), action on thiol-disulfide metabolism in the healthy Ratta albicans kidneys were studied. The animals were divided in 6 groups of 7 rats each. The control group included healthy rats which were injected i/m physiological solution 3 times a week, for 30 days. The rats from groups 2-6 have got 3 times a week, for 30 days, i/m injections of CCC. The activity of following thiol-disulfide metabolism enzymes in the renal supernatant has been measured: glutathion-reductase (GR), glutathion-peroxidase (GPO), glutathion-S-transferase (G-S-T), γ-glutamyl transpeptidase (γ-GTP), glutaredoxin (Grx), as well the amount of the protein SH-groups and of the total glutathione, reduced glutathione (GSH) and oxidized glutathione (GSSG) in renal tissue. Results: The compounds exhibit different actions: CMT-67 in the dose of 0.1 μM/kg influenced the activity of the glutathione metabolism enzymes – activated γ-glutamyl transpeptidase (γ-GTP) and glutaredoxine (Grx) and inhibited glutathione reductase (GR), while CMD-4 in doses of 0.1 μM/kg and 1.0 μM/kg and CMJ-33 in the dose of 1.0 μM/kg significantly diminished the reduced glutathione (GSH) level and increased the amount of the oxidised one (GSSG). Conclusions: Selective action of the copper coordination copounds established by this study opens new possibilities of their usage in the therapy of kidney diseases. |
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Cuvinte-cheie thiol-disulfide metabolism, copper coordination compounds, kidney tissue |
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