Using of new hybrid compounds with terpenoid and azaheterociclic skeleton to increase antioxidant activity of the Nostoc Linckia
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RUDIK, V., ARICU, Aculina, KUCHKOVA, Kaleria, CEPOI, Liliana, RUDI, Ludmila, CODREANU, Svetlana, SECARA-KUȘNIR, Elena, VALUŢĂ, Ana, BARBA, Alic, MISCU, Vera, VLAD, Pavel, CHIRIAC, Tatiana. Using of new hybrid compounds with terpenoid and azaheterociclic skeleton to increase antioxidant activity of the Nostoc Linckia. In: Physical Methods in Coordination and Supramolecular Chemistry, 8-9 octombrie 2015, Chişinău. Chisinau, Republic of Moldova: 2015, XVIII, p. 130.
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Physical Methods in Coordination and Supramolecular Chemistry
XVIII, 2015
Conferința ""Physical Methods in Coordination and Supramolecular Chemistry""
Chişinău, Moldova, 8-9 octombrie 2015

Using of new hybrid compounds with terpenoid and azaheterociclic skeleton to increase antioxidant activity of the Nostoc Linckia


Pag. 130-130

Rudik V.1, Aricu Aculina2, Kuchkova Kaleria2, Cepoi Liliana1, Rudi Ludmila1, Codreanu Svetlana1, Secara-Kușnir Elena2, Valuţă Ana1, Barba Alic2, Miscu Vera1, Vlad Pavel2, Chiriac Tatiana1
 
1 Institute of Microbiology and Biotechnology ,
2 Institute of Chemistry
 
Disponibil în IBN: 22 aprilie 2020


Rezumat

The application of potentially toxic compounds in very low quantities can cause a moderate stress, leading to the intense accumulation in biomass of antioxidant compounds, without cellular components damage. This paper describes the test results of two new chemical compounds with terpenoid and azaheterociclic hybrid skeleton as inductor to provide high antioxidant activity of Nostoc linckia biomass. Below are presented the schemes of the synthesis process.schemeScheme for the preparation of 1-(8,13-bicyclohomofarnesenoil)-3-amino-1,2,4-triazole. The compounds were added to the nutrient medium of cyanobacteria N. linckia, in the amounts indicated in the table. The antiradical activity of the ethanolic extract obtained from cell biomass was determined using DPPH assay. The results are shown in the table. The antioxidant activity of 70% (1 mg/ml) ethanolic extract of Nostoc linckia biomass resulting from the chemical stimulationtableThe results show increased antioxidant activity of the ethanolic extract from 2.11 to 2.73 times compared to the control. With increasing antioxidant activity of then ethanol extract grows the value of Nostoc biomass as an antioxidant producer.