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Ultima descărcare din IBN: 2023-09-20 15:19 |
Căutarea după subiecte similare conform CZU |
616.36-02-071 (1) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1748) |
SM ISO690:2012 PELTEC, Angela. Elevated hemoglobin influences the risk of nonalcoholic fatty liver disease. In: Sănătate Publică, Economie şi Management în Medicină , 2015, nr. 4(61), pp. 58-63. ISSN 1729-8687. |
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Sănătate Publică, Economie şi Management în Medicină | |||||||
Numărul 4(61) / 2015 / ISSN 1729-8687 /ISSNe 2587-3873 | |||||||
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CZU: 616.36-02-071 | |||||||
Pag. 58-63 | |||||||
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Rezumat | |||||||
Nonalcoholic fatty liver disease (NAFLD) has become increasingly recognized as a public health problem around the word, which has become endemic in the industrialized countries. The etiology of NAFLD remains unknown, but specialists have established a strong association with age, gender, body mass index (BMI), body iron status and individual components of the metabolic syndrome (MS) such as type 2 diabetes, hypertension and hyperlipidemia. There is evidence supporting the view that hemoglobin may serve as a marker for injuries and diseases associated with glycemia, oxidative stress, hypertension, insulin resistance, obesity, and diabetes. Body iron levels play a critical role in NAFLD and the MS. Elevated hemoglobin levels may cause increased blood viscosity and decreased blood flow to the liver leading to hypoxia-related liver damages. The multivariate analysis showed that hemoglobin level is a good predictor for individuals with suspected NAFLD with or without the MS. Inflammation could lead to anisocytosis via release of immature red blood cells into the peripheral circulation. Increased red blood cell distribution width (RDW) in patients with hepatosteatosis compared to healthy controls is not surprising, because hepatosteatosis is associated with a subclinical inflammation. Body iron levels are important risk factor for NAFLD and incorporation of body iron levels as a predictor may help to prevent liver damages in patients with NAFLD. The dysmetabolic iron overload syndrome (DIOS) is detected in about one third of patients with NAFLD and the MS. All of these settings suggest that hemoglobin test should be considered as a part of clinical evaluation for patients with NAFLD. |
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Cuvinte-cheie nonalcoholic fatty liver disease, hemoglobin level, iron overload, dysmetabolic iron overload syndrome |
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