Papilloma viral infection is found in all parts of the globe and highly contagious. PVI is a high contagious infection, Last time human papillomavirus takes attention of different spetia lists, because it initiates malignant diseases. The article contains the characteristic of human papillomavirus, that cause the malignance tissue. The frequent occurrence of HPI among women of childbearing age, the possibility of vertical transmission of the virus, a feature of the course of infection during pregnancy, the irrationality of therapy – determine the interest in studying this problem. High prevalence of human papilloma viral infection, lack of organized screening, an organized cytological registry and quality-controlled cytology can be the reasons of the low success rate in implementation of cancer prevention programs. There is a need of studies of human papilloma virus (HPV) prevalence, a need of national screening programs, development of laws regulating use of HPV vaccine.