Small and medium-sized enterprises have a more prominent role in the economy, acting as a tool for regulating economic relations between sectors of the economy and the population. The relevance of the topic of the work lies in the fact that small business plays a significant role in the development of national economy of the country, as well as a single region. The subject of the study is the regional features of the development of small entrepreneurship in the Republic of Moldova. The analysis of the structure of small and medium-sized enterprises by main types of activity showed that the largest share belongs to “wholesale and retail trade; repair of motor vehicles and motorcycles.” The purpose of this research is to analyse the current state of small business development in Moldova, and develop recommendations for improving the development of regions and state support for small and medium-sized enterprises.