Plum cultivation in the Republic of Moldova is particularly important, due to the popularity of its fruits, which are used fresh and in processed products. The safety of obtaining plum production is largely affected by the parasitic impact of invasive nematode complexes associated with harmful insects, which largely compromise the fruit yield and tree health, being dependent on the degree of infestation, the abundance of pests and the diversity of species. This argument summarizes the purpose of the research, which provided suggestions in establishing the invasive impact and consequences of these pests to plum plantations, during the growing season, in fruit production associations. Phytosanitary surveys were done in various areas on intensive plum orchards with various modern cultivars, by collecting soil samples and affected organs, which were later analysed in the laboratory. For entomological research, the insects were simultaneously captured manually from the trees, sampled in test tubes, and later fixed and taxonomically determined. From collected species, the harmful ones were separated by establishing the parasitic diagnosis and taxonomic diversity. As a result of phytosanitary investigations and laboratory analyses, the presence of 15 species of invasive nematodes and viral vectors of the following genera were detected: Pratylenchus, Paratylenchus, Rotylenchus, Ditylenchus, Criconemoides, associated with vector species of pathogenic viruses of the genera: Xiphinema sp., Longidorus sp., Trichodorus sp. Besides, 12 species of invasive arthropods were detected: plum fruit moth (Cydia funebrana); midges (Dasineura spp.); species of wasps (Hoplocampa minuta, Hoplocampa flava, Eurytoma schreineri); mealy plum aphid (Hyalopterus pruni), green peach and plum aphid (Myzus persicae), red spider mite (Tetranychus urticae), gall (Eriophyes pruni), clover mite (Bryobia praetiosa), green leafhopper (Cicadella viridis), weevil (Sciaphobus squalidus), various species of moths etc. At the same time, the presence of 5 viral diseases with specific pathogenic effect was detected in plum orchards, with average intensity of 5-15%, detected practically in all investigated orchards, and the estimated invasive impact caused by arthropod species was characterised by a degree of attack from 8% to 30%, with prevalence on leaves and young shoots.