Since such a large number of pharmaceutical compounds are consumed every year, significant unused overtime drugs, including human and veterinary medical compounds, are released into environment continuously. A large part, in the form of original drugs or metabolites, is discarded to waste disposal site or into municipal sewer (human body only metabolizes a small percentage of drug). Much of these medicines escape from being eliminated in wastewater treatment plants, because they are soluble or slightly soluble, and they are resistant to degradation through biological or conventional chemical processes. Considering that conventional wastewater treatment processes display sometime poor removal efficiency for pharmaceuticals, the aim of this paper is to increase degradation/ mineralization efficiency of sodium diclofenac using chemical advanced oxidation processes. To achieve the goal, the catalytic oxidation of the model systems was carried out with the Fenton reagent (DFC/H2O2/Fe2+) for 60 min at room temperature. The analysed systems contain sodium diclofenac with an initial concentration of 50 mg/L. The degradation kinetics of sodium diclofenac from aqueous solutions was estimated by the variation of DCF concentration (Ct), determining the reaction rates (Δc/Δt, molL-1s-1, rate constants (kt, s-1) and the half-life (τ1/2, s). The oxidation/mineralization was monitored by the variation of residual compounds (CODt). Based on the obtained results, it can be observed that upon the oxidation of 50 mg/L DFC from aqueous solution with Fenton's reagent, the highest degradation/mineralization performance was obtained: a rate constant (k) of 2.7·10-3 s-1, a reaction rate (Δc/Δt) of 2.1 ·10-7 molL-1s-1, and a half-life (τ1/2) of 256 s, compared to Photo-Fenton and Sono-Fenton oxidation. These results are due to the fact that in the presence of Fe2+ ions, aqua ferric ions are formed in large quantities, which at pH 2.5 have a strong catalytic activity. Therefore, interacting with hydrogen peroxide it forms OH radicals, which leads to an almost complete conversion in the first 3 min of reaction and oxidizes the pollutant to less toxic organic compounds. Thus, the degradation and the oxidation/mineralization are, on average, 80%. It may be concluding that the effect of each independent variable depends on the value of the other due to the existence of simultaneous interactions. Thus, any of the variables could positively or negatively affect both the degradation and mineralization rate of sodium diclofenac. It was concluded that catalytic process can be a potential method for removal sodium diclofenac in optimal conditions.