Optimizing our daily habits to balance the interactions between environmental factors, activity, and homeostatic factors in the internal environment results in improved quality and quantity of sleep, quality of wakefulness, metabolism, and overall health. The goal is to test an experimental model of circadian rhythm desynchronosis caused by eating behavior and environmental conditions. The experiment used laboratory animals (rats) (n = 20) raised in a vivarium. Motor activity was recorded using an actigraph (ActiGraph wGT3X-BT). Motivated eating behavior was stimulated by the use of hedonic food during the rest period after daily food deprivation, and physical activity was forcibly induced in a rotating cage during the rest period and during the active period. Statistical analysis was performed using Student's t-test. The results indicate that after a period of wakefulness in conditions of physiological rest under natural light and with normal eating behavior with the use of a standard diet, the examined laboratory animals show increased motor activity in the dark within 800 units for every 2 hours. Whereas during daylight hours and at a standard meal, activity is 350 units during a meal and 150 units after a meal. During the use of hedonic food, motor activity was about 500-600 units, and at night 700-800 units. Violent desynchronosis at night caused significantly higher motor activity up to 1400 (P<0.01), and during daylight hours motor activity was significantly higher (P<0.01) compared to physiological rest. We assume that environmental influence (violent desynchronosis) and food behavioral influence (hedonic diet) cause synergistic activation of the central oscillator in the suprachiasmatic nucleus and the orexinergic activating system of the lateral region of the hypothalamus. Thus, the activation of the interaction and synergistic effect of both central oscillators during the rest period contributes to the destruction of the natural circadian rhythm, excessive activity during the active period, as well as an imbalance in eating behavior and homeostatic metabolic rhythmic processes.