Environmental pollution caused by use of pesticides, has led to considerable changes in people’s attitudes towards the use of pesticides in agriculture. Under such circumstances biological control to be the most appropriate alternative to chemicals. (Kumar 2012 ; Senthil-Nathan 2015 ). Products of microbial origin in combination with para-aminobenzoic acid (PABA) derivatives can be the basis for organic farming and plant resistance to unfavorable environmental factors inducing, as well as for the crop yield increasing. The aim of the work the results of the study of efficiency of fruit-cultures and potato plantations treatment with aqueous suspensions of entomopathogenic bacteria Bacillus thuringiensis subsp. kurstaki and Bacillus thuringiensis var. thuringiensis with addition of para-aminobenzoic acid derivatives solutions in concentrations 10-2, 10-4, 10-6 mol/l. An increase in the average weight of fruits and tubers and a reduction in disease and insect damage were observed in all variants of the experiment compared to the control. The studied derivatives exhibited higher biological activity at the lower concentration than PABA. The best trial was treatment with a mixture of Bacillus thuringiensis subsp. kurstaki with the addition of an aqueous solution of PABA at concentrations of 10-4 and 10-6 mol/l. It was shown that the use of Bacillus spp. with the addition of the para-aminobenzoic acid derivatives solutions, leads to an improvement in the functional state of plants, contributing to the activation of the active resistance mechanisms to the action of the stress factors. The results obtained demonstrate the possibility of using entomopathogenic bacteria in a tank mixture with PABA for the creation of biological preparations as alternatives to pesticides and the development of biological methods of plant protection.