Plant pathogenic microorganisms cause serious economic damage, not only because they directly destroy crops, but also because producers spend significant outlays for effective protection against the pathogens. A possible solution for to reduce economic losses without damaging the environment and at the same time maintain high crop quality is using the natural enemies for protection against pathogens. For instance, specific bacterial viruses - bacteriophages - can be used to control bacterial diseases. The aim of the research was to compare the effect of Erwinia amylovora bacteriophages in the control of fire blight with the system of protection against the bacteriosis, used in the quince orchard. For this purpose, experimental plants were treated with the Erwinia amylovora bacteriophages, which we had previously isolated from plants affected by fire blight and identified by the major capsid protein based multiplex PCR assay. The concentration of phages suspension was 106 PFU/l. Treatments with bacteriophages were carried out during full quince blossoming, critical for fire blight infection and when any treatments with pesticides are forbidden, and in the periods with the highest risk of the pathogen development. The other trees in the orchard were treated with Copflo super SC according to the recommended application scheme. Experiments were carried out in the quince orchard in the Central part of the Republic of Moldova. No difference was observed between the degree of fire blight attack on the quince plants in the experiment and those treated with Copflo super SC preparation at the end of the growing season. As well as no difference in the fruit quality has been noticed between the plants in the experiment and in the other orchard. Thus, the timely application of bacteriophages kept the development of the fire blight at the same level as the chemical means of the quince orchard protection provided.