Starting from increasing the impact of phytosanitary agents and deepening the ecological problems caused by their combat, it becomes rational to change the paradigm of the protection of plants with their health. As effective measures in promoting plant health, it is proposed to apply the link between soil, plant and human health, the role and place of GMOs in solving phytosanitary problems, the perspectives of genome editing, the expansion of the implementation of regenerative agriculture. In order to overcome this problem, the paper contains information on the possibilities of application of synergic phenomena in plant protection, the interaction between which provides a significant increase in performance indicators and stability of the system state.