Regional development in Moldova is a necessity assumed by Law no. 438-XVI from 28.12.2006. The regional development model provides the division of the country territory into 6 regions and is based on the country’s sustainable economic development. In this regard, the natural areas protected by the state have a special role. Due to their special protection status they ensure the conservation of natural resources in the region. The work is focused on some aspects of the ecological status of state protected natural areas in the Northern Region. The results were obtained on the basis of a comprehensive study conducted during field expeditions and laboratory research over several years. There are highlighted valuable items specific for protection category and the ecological state of biotic and abiotic components. As a result of the research it was found that the specific elements for the categories of investigated areas are in satisfactory condition. The investigated natural ecosystems, especially those located in the forestry sector; provide favorable conditions for a rich diversity of plant and animal species, among them rare species protected at the national and international level. Interconnection between biotic and abiotic components of protected areas and surrounding habitats, especially agrocoenoses ensure ecological balance in the region.