Water quality management from underground sources has become, in the last decades, one of the main challenges faced by human society, being crucial in the context of ensuring the daily consumption demands of the population. The attempt to preserve a good water quality obtained from aquifers and the urge to rehabilitate groundwater bodies affected by pollution has generated the need for sustainable management to be established. In order to achieve this purpose, several sets of regulations and measures were implemented, aimed at managing these resources. The pressure to which the aquifers are exposed and the challenge to prevent the qualitative alteration of groundwater has conducted to the development of predicting models for the vulnerability of natural and anthropogenic environments to pollution with compounds derived from the fields of activity of human society, the DRASTIC model being one of them. At the Botoșani county level, the main geological and hydrological factors that potentially impact aquifer pollution were taken into account. Several raster datasets were generated such as depth to water table (D), aquifer recharge (R), aquifer type (A), soil texture (S), topography (T), vadose zone’s impact (I) and hydraulic conductivity (C). For each factor were assigned grades between one and ten according to the overall importance, so the vulnerability map was generated by combining the seven individual layers. The DRASTIC index obtained varies between 89 and 175, indicating that the relative vulnerability of the aquifers varies between medium and very high. The high vulnerability class has a uniform distribution, while, the very high vulnerability class presents a layout mostly in the western and northeastern parts of the county. The medium vulnerability class can be found in the southeastern part of the study area, covering a region where the depth up to the water table and also the soil texture, does not favour good water descending on the soil profile.