Introduction: HIV/AIDS represents a very major and serious disease affecting more and more people early age. At the end of 2010 an estimated - 34 million [31.6 million – 35.2 million] people globally living with HIV, 2.7 million [2.4 million – 2.9 million] new HIV infections in 2010, 1.8 million [1.6 million – 1.9 million] people died of AIDS-related illnesses in 2010. According to CDC published, new incidence of HIV infections estimates in 2011 showed that the annual number of new HIV infections was stable overall from 2006 through 2009. According to UNAIDS and WHO estimates, 47% (6.6 million) of the estimated 14.2 million people eligible for treatment in low- and middle-income countries were accessing lifesaving antiretroviral therapy in 2010, an increase of 1.35 million since 2009. The 2011 UNAIDS World AIDS Day report also highlights that there are early signs that HIV treatment is having a significant impact on reducing the number of new HIV infections. In Moldova, during 1987-2007 there were detected 4201 HIV infected persons, including the territories from the right bank of the eastern territories of the republic, 2939-1192 people and 70 foreigners. Methods: This article reflects the information given population through computerization and flashmob organization to the World Day in order to combat HIV / AIDS – December 1. The following methods were used: observation, epidemiological, historical, economic and demographic. For further computerization and HIV / AIDS 27 students of “Nicolae Testemitanu” State Medical and Pharmaceutical University performed a flash mob in Chisinau center for the population. Results: Work done in informing people has increased the knowledge about this disease. Goals, objectives, strategies and activities for implementation in infections disease control, combating HIV/AIDS is provided in the National Health Policy of the Republic of Moldova, Law “On HIV/AIDS”. Conclusion: It’s necessary continuously to monitor the epidemiological situation of the HIV infections in developing preventive measures.