The experience gained through European integration and extension enabled the observation of certain dissimilarities, incompatibilities, and incongruences noticed in the frontier areas, generated by the so-called reflex of ”castle under siege” inherited from the national states members in the European Union. Consequently, the first cross-border partnerships have been established even since the end of the 60’s in order to facilitate circulation and local unload of the differences in potential among neighboring territories, situated on one side or another of national frontiers. The success of the first models will bear fruit later on, in an area with much higher needs of this kind than the Western Europe, i.e. the space of Medial Europe.