Much attention has been devoted to development and especially to the human capital, as its major catalyzer. Nowadays, the economic and political challenges that developing countries are going through, lead to serious changes into the structure and movement of the qualified human capital. Republic of Moldova faces severe migration problems. Unfavorable economic conditions, the existence of better opportunities abroad are creating those push-factors that day by day worsen the situation. The amplitude of this phenomenon accentuates the importance of efficient intellectual potential xodus management. This article aims to present general trends of intellectual potential exodus phenomenon in Republic of Moldova with recommendations of possible strategies that could be applied in order to reduce the bad effects and to increase positive effects, by analyzing the experience of other countries which have obtained better results in brain drain management.