The study was carried out in laboratory conditions and in the field experiment in the forest-steppe zone of Western Siberia. The protective effect of seed treatment with biofungicides Trichodermin and Sporobacterin in combination with spraying wheat crops with Fitosporin against root rot, the growth effect in the synergism of the biological properties of drugs was studied. It is shown that under the greening growth conditions of wheat, it is possible to replace the combination of chemical treatments with biological ones while maintaining a high level of productivity. The mechanism of influence of some combinations of drugs, revealing the peculiarities of biochemical processes in the cells of flag leaves of plants, on the forecast of productivity at the early stages of plant development has been revealed.