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SM ISO690:2012 REVENCO, Valeriu, ABRAŞ, Marcel. Lercanidipina: aspecte de eficienţă antihipertensivă şi pleiotropism. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 26-32. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 26-32 | ||||||
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Rezumat | ||||||
Lercanidipine: issues of antihypertensive efficiency and pleiotropism
In this article have been discussed the antihypertensive efficacy of lercanidipine, a new
dihydropyridine calcium channel blocker of the third generation, compared with other CCBs and
other antihypertensive agents. Its main advantage over first- and second-generation CCBs is less
incidence of adverse effects, such as reflex tachycardia and peripheral edema. The improved
tolerability profile of lercanidipine might help to partly overcome the problem of the poor
adherence to antihypertensive therapy. Recent data suggest that lercanidipine have some
pleiotropic renoprotective, antioxidant, antihypertrophic properties, could improve insulin
resistance in diabetic patients and in patients with metabolic syndrome. |
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